Local Hemodynamic Forces After StentingHighlights
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Local Hemodynamic Forces After Stenting
Advances in stent technology, drug polymer biocompatibility, and design have improved the safety and efficacy of coronary stent devices. Despite these advances, restenosis and device thrombosis remain a major concern and are still affecting long-term clinical outcomes. Randomized trials and clinical registries show that the rate of stent thrombosis is <1% after 1 year, and the restenosis rates ...
متن کاملEndothelial Dysfunction, Hemodynamic Forces, and Atherogenesisa
Phenotypic modulation of endothelium to a dysfunctional state contributes to the pathogenesis of cardiovascular diseases such as atherosclerosis. The localization of atherosclerotic lesions to arterial geometries associated with disturbed flow patterns suggests an important role for local hemodynamic forces in atherogenesis. There is increasing evidence that the vascular endothelium, which is d...
متن کاملCommentary Vascular Endothelium, Hemodynamic Forces, and Atherogenesis
Intimal lipid accumulation, hyperplasia, and scarring are stigmata of atherosclerotic vascular disease, whose major complications—myocardial and cerebral ischemia and infarction—continue to be major health problems in developed nations. This insidiously progressive disease typically spans decades, but can reach a clinical horizon in a matter of minutes due to critical changes in a given atheros...
متن کاملMechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
RATIONALE PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether genome-wide association studies-identified coronary artery disease genes, including PPAP2B, participate in mech...
متن کاملHemodynamic forces are complex regulators of endothelial gene expression.
Vascular endothelial cells, by virtue of their unique anatomical position, are constantly exposed to the fluid mechanical forces generated by flowing blood. In vitro studies with model flow systems have demonstrated that wall shear stresses can modulate various aspects of endothelial structure and function. Certain of these effects appear to result from the regulation of expression of endotheli...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2017
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.117.309728